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2011年7月28日星期四

About Thromboxane

Thromboxane is a member of the family of lipids known as eicosanoids. The two major thromboxanes are thromboxane A2 and thromboxane B2. The distinguishing feature of thromboxanes is a 6-membered ether-containing ring.
Thromboxane is named for its role in clot formation (thrombosis).
It is a vasoconstrictor and a potent hypertensive agent, and it facilitates platelet aggregation.It is in homeostatic balance in the circulatory system with prostacyclin, a related compound. The mechanism of secretion of thromboxanes from platelets is still unclear.
It is believed that the vasoconstriction caused by thromboxanes plays a role in Prinzmetal's angina. Omega-3 fatty acids have higher levels of TxA3 which is relatively less potent than TxA2 and PGI3; therefore, there is a balance shift toward vasoconstriction and platelet aggregation inhibition. It is believed that this shift in balance lowers the incidence of myocardial infarction and stroke.

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