The Toxicity of chlorfluazuron

In laboratory animals, chlorfluazuron had very low acute toxicity if ingested, inhaled or exposed on the skin. It was slightly irritating to the eyes but did not cause skin irritation or allergic reactions when applied to the skin. Chlorfluazuron was absorbed only to a limited extent when swallowed and excreted mainly in the faeces.
Short and long-term exposure to low concentrations of chlorfluazuron in the diet was without serious consequences in animal studies. The only consistent finding was an increase in cholesterol levels. Chlorfluazuron did not cause birth defects in laboratory animals.
There is evidence to indicate that chlorfluazuron persists and bio-accumulates in the body. In rats, high levels of chlorfluazuron residues were deposited in fat and depletion was slow, with a depletion half-life of approximately 42 days. Goats and hens secreted chlorfluazuron into milk and egg yolk, respectively. If given in the diet of food-producing animals, there is a significant potential for accumulation and retention of residues in the fat and for excretion in milk.
As chlorfluazuron is used in subterranean termite baiting stations, public exposure is unlikely to occur. However, due to its persistent and bio-accumulative nature, care needs to be taken not to misuse the chemical.

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